Objective: To probe into the clinical distribution characteristics

drug resistance and risk factors of multi-drug resistant Acinetobacter baumannii (MDRAB) infection isolated from sterile body fluid specimens of pediatric inpatients. Methods: Drug sensitivity tests results of 99 strains of A. baumannii isolated from sterile body fluid specimens of pediatric inpatients in the First Affiliated Hospital of Guangxi Medical University from 2012 to 2018 were retrospectively analyzed

the risk factors of A. baumannii infection were investigated by multi-factor method. Results: The largest number of A. baumannii strains was isolated from the pediatric intensive care unit (PICU)

accounting for 68.7%. Among all kinds of sterile specimens

the most common samples were lower respiratory tract specimens

accounting for 52.5%. A. baumannii showed higher drug resistance rate to β-lactam antibiotics

and lower drug resistance rate to cefoperazone/sulbactam. The risk factors for MDRAB infection were the categories of antibiotics ≥3

mechanical ventilation

endotracheal intubation and indwelled central venous catheter

of which indwelled central venous catheter was the independent risk factor. Conclusion: Clinical monitoring of drug resistance in A. baumannii should be strengthened

so as to provide reference for the rational selection of antibiotics in pediatrics.